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Study record managers: refer to the Data Element Definitions if submitting registration or information. Podoconiosis non-filarial elephantiasis affects some of the poorest people in 20 countries in the world. In Ethiopia least 3 million people are affected with 17 million at risk. Irritant minerals smectite, mica and quartz from volcanic soil and pathogens enter skin breaches in the feet causing inflammation, lymphoedema and hyperkeratosis.
Podoconiosis is preventable and treatable but is not curable. Current treatment consists of educating those with disease on its causes, prevention and treatment. Whitfields ointment benzoic acid and salicylic acid is applied to any fungal infections. Wearing shoes is encouraged but this does not offer complete protection against the alkaline soil. Although the current treatment skin care regimen is effective there is no robust evidence on optimal skin care regimens to improve skin barrier function in this disease.
To evaluate the effectiveness of a new, low-cost, evidence-based skin care intervention to improve SBF in the lower limbs of those with podoconiosis. The control group received the current skin care regimen. The primary outcome measure was skin barrier function SBF. This was determined by measures of trans-epidermal water loss TEWL and stratum corneum hydration SCH at four specific sites on the lower limbs.
TEWL is the water lost through the skin under non-sweating conditions. It is the major indicator of healthy skin. A reduction in TEWL indicates a positive effect on skin barrier function. It is generally recommended that differences or percentage changes are reported rather than absolute values.
This was mid-way between the measurement site at the top of the outer leg and the site at the base of the outer lower leg. Trans-epidermal water loss TEWL was measured with a Vapometer non- invasive probe at a specific point on the top of the foot. Breaches in the skin and areas of fungal infection are more likely to occur in those with an impaired skin barrier function. A reduction in the of wounds indicates an improvement in SBF. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to a study.
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Warning You have reached the maximum of saved studies Listing a study does not mean it has been Looking for sbf Mossy Point by the U. Federal Government. Read our disclaimer for details. First Posted : January 6, Last Update Posted : January 6, Study Description.
Detailed Description:. Drug Information available for: Glycerin. FDA Resources. Arms and Interventions. Outcome Measures. Trans-epidermal water loss TEWL was measured with a Vapometer non- invasive probe at a specific point on the outer lower leg. Trans-epidermal water loss TEWL was measured with a Vapometer non- invasive probe at a specific point on the outer lower leg 8cms above the external malleolus. Stratum corneum hydration was measured at a specific point at top of outer lower leg 8cms below the head of the fibula with a MoistureMeter non-invasive probe.
This measures skin capacitance in arbitrary units. Increases in stratum corneum hydration indicate a positive effect on skin barrier function. SCH was measured mid-way between the measurement site at the top of the outer leg and the site at the base of the outer lower leg. It was measured with a MoistureMeter non-invasive probe. Stratum corneum hydration was measured at the base of the outer lower leg 8 cms above the external malleolus.
Stratum corneum hydration measured at a specific point on the middle top of the foot with a MoistureMeter non-invasive probe. This staging system was specifically deed Looking for sbf Mossy Point those with podoconiosis. Trophic changes were either present or not present. Bad odour in social stigma and impacts of quality of life. Verbal questioning of participants by clinic nurse or social worker as to of work days lost due to severe leg pain adenolymphangitis. Questioning was used as most participants were illiterate.
Measured by clinic nurse in centimetres with a disposable tape measure at the point of largest circumference on the foot. The index is divided into 4 sections covering leisure, work and school, personal relationships and treatment. The maximum score of 30 indicates a high impact on quality of life.
The lowest score zero. A reduction in the indicates an improvement in quality of life. Participants were verbally questioned by the clinic nurse or social worker as most participants were illiterate. Eligibility Criteria. Inclusion Criteria: Patients in Ethiopia with a diagnosis of podoconiosis.
That is those living above feet sea level with high rainfall, above 1,00mm annually with foot or lower leg oedema which had started in the feet, with sensation present in the feet and no hand involvement. The diagnosis was determined by the nurses at the outreach clinics. Patients who were able to understand instructions and give informed consent as determined by the nurses at the outreach clinics. Patients over 18 years of age.
Exclusion Criteria: Patients not diagnosed with podoconiosis as determined by nurses at the outreach clinics. Patients who were unable to understand instructions or give informed consent as determined by nurses at the outreach clinics. Patients under 18 years of age.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Non-filarial Elephantiasis. Phase 3. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :. July 21, Key Record Dates. Elephantiasis Lymphedema Lymphatic Diseases Glycerol.Looking for sbf Mossy Point
email: [email protected] - phone:(616) 330-7718 x 1948
An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis